From TV.com

Brennan, Booth and Angela go to the pediatric cancer ward to deliver the findings on their latest case to FBI Deputy Director Cullen. Brennan inquires about the strange choice of locale, and Booth informs her that Cullen's daughter, Amy, has been diagnosed with mesothelioma and while she is in the hospital, it is easier for Cullen's agents to come to him. Brennan is surprised by a diagnosis of mesothelioma in a patient so young, and despite Booth's protests, she questions the Cullen family about Amy's medical history. Cullen tells her that Amy suffered a compound fracture a short time ago and received a bone graft. Brennan requests to see the x-rays of Amy's bone graft, and Cullen readily gives permission, eager to share information with anyone who may be able to help Amy.

When Brennan and Zack examine the x-rays, they discover that the donor bone shows signs of osteoporosis and that the donor, who the hospital claims was 25 years old, was actually elderly. Brennan and Booth question the surgeon who performed Amy's bone graft, but he explains that he only performs the procedures and has nothing to do with procuring the donor bones. Brennan convinces him to do a bone biopsy to confirm her findings and ascertain whether Amy's mesothelioma originated in the bone graft. The biopsy confirms that the donor was in his or her 60's and the bone itself is riddled with cancer. Brennan and Booth question the hospital's transplant coordinator, Dr. Ogden, who gives them the name of the tissue bank the hospital works with, BioTech, and tells them that only the tissue bank will have the records stating from whom Amy's donor bone came.

Brennan and Booth share their findings with Deputy Director Cullen. Cullen asks if the team's discovery will have any effect on Amy's prognosis, and Brennan tells him that unfortunately it will not. Booth offers to track down the source of the donor bone and discover how it slipped through the system, but Cullen advises Booth to hand the case off to the CDC, as it is not FBI jurisdiction and Cullen does not want to use the FBI as his "personal police force". Rather than give up, Booth decides to continue working on the case "unofficially", knowing that if he can find evidence that any infected donor bones crossed state lines, he can legally claim jurisdiction for the FBI.

Meanwhile, Angela visits Amy in the hospital. They bonded on Angela's first trip to the hospital over their mutual love of art, and Angela has surprised Amy by digitizing one of Amy's own paintings and projecting it onto the wall of the hospital room. Amy confesses her fear of dying and her wish that she could somehow visit the Louvre, while Angela tries to reassure her that she will survive the cancer and someday see the famed museum.

When Brennan and Booth go to the headquarters of BioTech , they find nothing but a few empty boxes and desks. The building manager informs them that BioTech went bankrupt two years before, despite having supposedly sold Amy's bone graft to the hospital only one year before. They return to the hospital to question the transplant coordinator Dr. Ogden again, suspecting that he knew BioTech was bankrupt and was knowingly purchasing black market organs for his own financial gain. When they arrive, Dr. Ogden is not present, but his assistant, Alexandra, tells them that she did some investigating after they left the last time and found another patient who received two bone grafts on the same day as Amy, with a high likelihood that the grafts came from the same donor. Booth calls the FBI and gives them the name of the other patient, Kelly DeMarco, and finds that she is dead. Brennan gets permission to exhume Kelly's body and finds that her bone graft did indeed come from the same donor as Amy's.

When Booth does some digging into Dr. Ogden's background, he discovers that he was fired from his last job after taking a bribe to bump someone up the donor list. Booth calls Ogden down to the FBI building for questioning. Ogden admits to his previous wrongdoing, but insists that he had no idea BioTech had gone bankrupt, as his relationship with them was purely a virtual one, and all communication happened via email.

The team communicates with local hospitals to compile a list of people who received organ or bone donations from BioTech around the time of Amy's operation. They find one other victim who has already died, and because the victim lived in Virginia while the original victim lived in Maryland, the case becomes FBI jurisdiction and Booth can begin investigating officially. Brennan helps coordinate biopsies for the other living recipients and several of them are found to have early stages of cancer that have not yet metastasized. Amy begs Brennan to convince her doctors to remove the bone graft in her leg, but Brennan sadly tells her that because her cancer has already spread, removing the diseased graft will have no effect and she is too weak to undergo surgery.

Hodgins performs an isotope analysis on the bone grafts the team has collected and determines that the donor lived in West Virginia for at least the last 20 years or so. Booth searches for men in their 60's who died of mesothelioma in West Virginia around the time of Amy's surgery and comes up with three possibilities. Two of the bodies are examined and show no signs of tampering, but the third potential donor, William Hastings, was cremated, so there is no body to examine. Brennan and Booth interview Hastings' widow and Brennan asks permission to take a sample of the place in Mrs. Hastings' yard where William's ashes were spread, but Mrs. Hastings refuses, angry with the implied accusation that she may have sold her husband's body parts for money.

Brennan and Booth return to the Hastings home with a warrant, and upon examination they discover that the cremains in the back yard are consistent with the bone grafts taken from William Hastings. However, they find no suspicious financial transactions to indicate that Mrs. Hastings collected the substantial price offered for black market bone grafts. They get another warrant to search the funeral home where Mr. Hastings was cremated. They find that the owner, Nick Martin, has cleaned the place pretty thoroughly in anticipation of their arrival, but Brennan finds bone dust in one of the vents, which is later confirmed to contain trace amounts of William Hastings' bone, as well as the bones of at least seven other people.

The team realizes that Nick Martin was unlikely to be acting alone as harvesting bone grafts requires medical training and Mr. Martin has none. In examining Martin's phone records, Booth finds a number of phone calls originating from disposable cell phones, and Brennan remembers a stock of disposable cells kept by Alexandra, the transplant coordinator's assistant, for the purpose of alerting patients the moment a donor organ becomes available. She goes to the hospital to question Alexandra. She finds out that Alexandra attended medical school but did not finish. She also discovers that Alexandra is suffering from a cough and chest congestion, which Brennan recognizes as side effects of inhaling bone dust. Booth arrives and arrests Alexandra for murder.

Meanwhile, Angela is devastated by the news that Amy's experimental cancer treatment did not work, and there is nothing more the doctors can do for her. She expresses her frustration to Hodgins that while all their technology and ingenuity allows them to solve seemingly unsolvable crimes, they cannot help keep one little girl alive. With Hodgins' encouragement, Angela creates a virtual reality program that perfectly recreates the Louvre, in order to fulfill Amy's wish of seeing the museum before she dies.