“Exile On Main Street " – the episode’s title – is also the name of a double LP released by the Rolling Stones in 1972. It is an album that features songs that represent the genres that Sixties rock could be deconstructed back to -like blues, gospel, soul - a return to its roots. It was also recorded over a period of change and personal upheaval for the band although during the time Jagger also married and had a child. This is the third Supernatural episode named after a Rolling Stones song or album, the other two being 3.15 Time Is On My Side and 5.01 Sympathy For The Devil.

In the tradition of Supernatural, this season features a new Title Card

While under the Djinn’s influence Dean is scared by a Yorkie in his garage. In 4.06 Yellow Fever while affected with Ghost Sickness that heightens fear, Dean is chased by a Yorkie that he imagines is a hellhound. And back in 1.22 Devil's Trap when Sam and Dean let off the fire alarm in an apartment building in order to rescue John, Dean tells a fireman “I’ve got a Yorkie upstairs and he pees when he’s nervous....

Sam: Golf? Really?
Dean: It's a sport!
The golf reference is an in-joke - Jensen Ackles is an avid golfer.

Samuel: You know you had ancestors hacking the heads off vamps on the Mayflower.
The Mayflower was the ship that bought the Pilgrims from England to North America in 1620.